Staged development of long-lived T-cell receptor αβ T_H17 resident memory T-cell population to Candida albicans after skin infection.

ABSTRACT:

Background

Candida albicans is a dimorphic fungus to which human subjects are exposed early in life, and by adulthood, it is part of the mycobiome of skin and other tissues. Neonatal skin lacks resident memory T (T_RM) cells, but in adults the C albicans skin test is a surrogate for immunocompetence. Young adult mice raised under specific pathogen-free conditions are naive to C albicans and have been shown recently to have an immune system resembling that of neonatal human subjects.

Objective

We studied the evolution of the adaptive cutaneous immune response to Candida species.

Methods

We examined both human skin T cells and the de novo and memory immune responses in a mouse model of C albicans skin infection.

Results

In mice the initial IL-17-produci

SUBMITTER: Park CO 

PROVIDER: S-EPMC5943196 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature