Local IL-23 is required for proliferation and retention of skin-resident memory T_H17 cells.

ABSTRACT: The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that circulating memory T cells were dispensable for anamnestic protection from Candida albicans skin infection, and tissue-resident memory (T_RM) cell-mediated protection from C. albicans reinfection required IL-23. Administration of anti-IL-23 receptor antibody to mice after resolution of primary C. albicans infection resulted in loss of CD69⁺ CD103⁺ tissue-resident memory T helper 17 (T_RM17) cells from skin, and clinical anti-IL-23 therapy depleted T_RM17 cells from skin of p

SUBMITTER: Whitley SK 

PROVIDER: S-EPMC9847353 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature