Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling.

ABSTRACT: Synapses are constructed with the stability to last a lifetime, yet sufficiently flexible to adapt during injury. Although fundamental pathways that mediate intrinsic responses to neuronal injury have been defined, less is known about how synaptic partners adapt. We have investigated responses in the postsynaptic cell to presynaptic activation of the injury-related Dual Leucine Zipper Kinase pathway at the Drosophila neuromuscular junction. We find that the postsynaptic compartment reduces neurotransmitter receptor levels, thus depressing synaptic strength. Interestingly, this diminished state is stabilized through distinct modulations to two postsynaptic homeostatic signaling systems. First, a retrograde response normally triggered by reduced receptor levels is silenced, preventing a comp

SUBMITTER: Goel P 

PROVIDER: S-EPMC5945772 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature