Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse.
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ABSTRACT:
SUBMITTER: Park CJ
PROVIDER: S-EPMC5951291 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse.
Park Chan Jin CJ Chen Guanglin G Koo Yongbum Y Lin Po-Ching P PP Cacioppo Joseph A JA Prohaska Hailey H Ko CheMyong J CJ
Genesis (New York, N.Y. : 2000) 20171117 12
Two estrogen receptors, ESR1 and ESR2, are responsible for the classical actions of estrogens in mammalian species. They display different spatiotemporal expression patterns and nonoverlapping functions in various tissues and physiological conditions. In this study, a novel knock-in mouse line that expresses codon-improved Cre recombinase (iCre) under regulation of the natural Esr1 promoter (Esr1-iCre) was developed. Functional characterization of iCre expression by crossing them with reporter l ...[more]
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2025-04-12 | GSE284575 | GEO