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Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors.

ABSTRACT: BACKGROUND:Testicular cancer survivors (TCS) are at increased risk of cancer-related fatigue (CRF), psychosocial impairment, and poor mental health-related quality of life (HRQoL). Here, we examine the effects of high-intensity interval training (HIIT) on patient-reported outcomes (PROs) in TCS. Secondarily, we explore cardiorespiratory fitness as a mediator of intervention effects and select baseline characteristics as moderators of intervention effects. METHODS:TCS (n = 63) were randomly assigned to 12 weeks of supervised HIIT or usual care (UC). PROs included CRF, depression, anxiety, stress, self-esteem, sleep quality, and HRQoL assessed at baseline, post-intervention, and 3-month follow-up. RESULTS:TCS (median 7 years postdiagnosis) completed 99% of training sessions and achieved 98% of target training intensity. ANCOVA revealed that, compared to UC, HIIT significantly improved post-intervention CRF (p = 0.003), self-esteem (p = 0.029), and multiple HRQoL domains (ps ≤ 0.05). Effects on CRF (p = 0.031) and vitality (p = 0.015) persisted at 3-month follow-up. Cardiorespiratory fitness changes mediated CRF and HRQoL improvements. CRF effects were larger for TCS with an inactive lifestyle, lower fitness, higher testosterone, and clinical fatigue at baseline. CONCLUSIONS:HIIT significantly improves CRF and HRQoL in TCS. Mediation by cardiorespiratory fitness and moderation by clinical characteristics suggests opportunities for targeted exercise interventions to optimise PROs in TCS.

SUBMITTER: Adams SC

PROVIDER: S-EPMC5959855 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors.

Adams Scott C SC DeLorey Darren S DS Davenport Margie H MH Fairey Adrian S AS North Scott S Courneya Kerry S KS

British journal of cancer 20180508 10

<h4>Background</h4>Testicular cancer survivors (TCS) are at increased risk of cancer-related fatigue (CRF), psychosocial impairment, and poor mental health-related quality of life (HRQoL). Here, we examine the effects of high-intensity interval training (HIIT) on patient-reported outcomes (PROs) in TCS. Secondarily, we explore cardiorespiratory fitness as a mediator of intervention effects and select baseline characteristics as moderators of intervention effects.<h4>Methods</h4>TCS (n = 63) were ...[more]

PMID: 29736007

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Dataset Information

Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors.

Publications

Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors.

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