High neutrophil to lymphocyte ratio and decreased CD69⁺NK cells represent a phenotype of high risk in early-stage breast cancer patients.

ABSTRACT:

Purpose

Breast cancer (BC) is a highly heterogeneous disease presenting a broad range of clinical and molecular characteristics. In the past years, a growing body of evidence demonstrated that immune response plays a significant role in cancer outcome. However, immune prognostic markers are not completely validated in clinical practice in BC patients.

Materials and methods

With the aim to characterize immune features, several parameters were analyzed in peripheral blood at diagnosis of 85 nonmetastatic BC patients between April 2011 and July 2014.

Results

With a median follow-up of 38.6 months, peripheral blood analysis of BC patients (stages I, II, and III) showed that total lymphocyte and T lymphocyte counts were augmented in nonrelapsed patients. Also, a higher neu

SUBMITTER: Mando P 

PROVIDER: S-EPMC5961634 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature