Commensal Bacteria-Dependent CD8αβ⁺ T Cells in the Intestinal Epithelium Produce Antimicrobial Peptides.

ABSTRACT: The epithelium of the intestine functions as the primary "frontline" physical barrier for protection from enteric microbiota. Intraepithelial lymphocytes (IELs) distributed along the intestinal epithelium are predominantly CD8⁺ T cells, among which CD8αβ⁺ IELs are a large population. In this investigation, the proportion and absolute number of CD8αβ⁺ IELs decreased significantly in antibiotic-treated and germ-free mice. Moreover, the number of CD8αβ⁺ IELs was correlated closely with the load of commensal microbes, and induced by specific members of commensal bacteria. Microarray analysis revealed that CD8αβ⁺ IELs expressed a series of genes encoding potent antimicrobial peptides (AMPs), whereas CD8αβ⁺ splenocytes did not. Th

SUBMITTER: Chen B 

PROVIDER: S-EPMC5964211 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature