The design of a readily attachable and cleavable molecular scaffold for ortho-selective C-H alkenylation of arene alcohols.

ABSTRACT: We describe herein the design of a novel molecular scaffold that can induce facile oxidative olefinations when attached to alcohols. Benzylic, homo-, and bishomobenzylic alcohols are utilized. The scaffold can act as a protecting group for the alcohol in other transformations, and it is recoverable in excellent yield. The overall sequence can also be telescoped without purifications of intermediates, representing a net alcohol-based directed ortho-alkenylation.

SUBMITTER: Knight BJ 

PROVIDER: S-EPMC5966905 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature