Mn(ii)-Catalysed ortho-alkenylation of aromatic amines and its application in reproductive diseases.

ABSTRACT: A Mn(ii)-catalysed ortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl₂ was critical for the ortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds 3m on 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg^-13m after two weeks, while treatment with 10 mg kg^-13m led to obvi

SUBMITTER: Yang J 

PROVIDER: S-EPMC8690850 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature