Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells.
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ABSTRACT:
SUBMITTER: Kim SW
PROVIDER: S-EPMC5979625 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells.
Kim Sang-Woo SW Lee Yeon Kyung YK Hong Jeong Hee JH Park Jun-Young JY Choi Young-Ae YA Lee Dong Un DU Choi Jungil J Sym Sun Jin SJ Kim Sang-Hyun SH Khang Dongwoo D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20180226 5
Lung cancer is a highly malignant tumor, and targeted delivery of anti-cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti-cancer drugs for the treatment of malignant lung tumors can be decreased by more than 1 ...[more]
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