Metabolic perturbations in Welsh Ponies with insulin dysregulation, obesity, and laminitis.

ABSTRACT:

Background

Metabolomics, the study of small-molecule metabolites, has increased understanding of human metabolic diseases, but has not been used to study equine metabolic syndrome (EMS).

Objectives

(1) To examine the serum metabolome of Welsh Ponies with and without insulin dysregulation before and during an oral sugar test (OST). (2) To identify differences in metabolites in ponies with insulin dysregulation, obesity, or history of laminitis.

Animals

Twenty Welsh Ponies (mean ± SD; 13.8 ± 9.0 years) classified as non-insulin dysregulated [CON] (n = 10, insulin < 30 mU/L) or insulin dysregulated [ID] (n = 10, insulin > 60 mU/L) at 75 minutes after administration of Karo syrup, obese (n = 6) or nonobese (n = 14), and history of laminitis (n = 9) or no history of lamini

SUBMITTER: Jacob SI 

PROVIDER: S-EPMC5980341 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature