IL-9 Deficiency Promotes Pulmonary Th17 Response in Murine Model of Pneumocystis Infection.

ABSTRACT:

Introduction

Pneumocystis pneumonia (PCP) remains a severe complication with high mortality in immunocompromised patients. It has been well accepted that CD4⁺ T cells play a major role in controlling Pneumocystis infection. Th9 cells were the main source of IL-9 with multifaced roles depending on specific diseases. It is unclear whether IL-9/Th9 contributes to the immune response against PCP. The current study aims to explore the role of IL-9 and the effect of IL-9 on Th17 cells in murine model of PCP.

Materials and methods

Mice were intratracheally injected with 1 × 10⁶Pneumocystis organisms to establish the murine model of Pneumocystis infection. Pneumocystis burden was detected by TaqMan real-time PCR. Using IL-9-de

SUBMITTER: Li T 

PROVIDER: S-EPMC5980981 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature