Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals.
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ABSTRACT:
SUBMITTER: Blomeley C
PROVIDER: S-EPMC5983352 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals.
Blomeley Craig C Garau Celia C Burdakov Denis D
Nature neuroscience 20171127 1
Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretins) enhance innate risk-avoidance via poorly understood neurocircuits. We describe a direct orexin→D2 excitatory circuit and show that D2 cell activity is necessary for orexin-dependent innate risk-avoidance in mice, thus revealing an unsuspected hypo ...[more]
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