Steady-State Differential Dose Response in Biological Systems.

ABSTRACT: In pharmacology and systems biology, it is a fundamental problem to determine how biological systems change their dose-response behavior upon perturbations. In particular, it is unclear how topologies, reactions, and parameters (differentially) affect the dose response. Because parameters are often unknown, systematic approaches should directly relate network structure and function. Here, we outline a procedure to compare general non-monotone dose-response curves and subsequently develop a comprehensive theory for differential dose responses of biochemical networks captured by non-equilibrium steady-state linear framework models. Although these models are amenable to analytical derivations of non-equilibrium steady states in principle, their size frequently increases (super) exponentially

SUBMITTER: Yordanov P 

PROVIDER: S-EPMC5985043 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature