NAMPT-mediated NAD⁺ biosynthesis is indispensable for adipose tissue plasticity and development of obesity.

ABSTRACT:

Objective

The ability of adipose tissue to expand and contract in response to fluctuations in nutrient availability is essential for the maintenance of whole-body metabolic homeostasis. Given the nutrient scarcity that mammals faced for millions of years, programs involved in this adipose plasticity were likely evolved to be highly efficient in promoting lipid storage. Ironically, this previously advantageous feature may now represent a metabolic liability given the caloric excess of modern society. We speculate that nicotinamide adenine dinucleotide (NAD⁺) biosynthesis exemplifies this concept. Indeed NAD⁺/NADH metabolism in fat tissue has been previously linked with obesity, yet whether it plays a causal role in diet-induced adiposity is unknown. Here we inv

SUBMITTER: Nielsen KN 

PROVIDER: S-EPMC6001355 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature