Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

ABSTRACT: Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied decease

SUBMITTER: Hernandez-Fuentes MP 

PROVIDER: S-EPMC6001640 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature