Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.

ABSTRACT:

Purpose

Cellular immune dysfunctions, which are common in intensive care patients, predict a number of significant complications. In order to effectively target treatments, clinically applicable measures need to be developed to detect dysfunction. The objective was to confirm the ability of cellular markers associated with immune dysfunction to stratify risk of secondary infection in critically ill patients.

Methods

Multi-centre, prospective observational cohort study of critically ill patients in four UK intensive care units. Serial blood samples were taken, and three cell surface markers associated with immune cell dysfunction [neutrophil CD88, monocyte human leucocyte antigen-DR (HLA-DR) and percentage of regulatory T cells (T_regs)] were assayed on-site using s

SUBMITTER: Conway Morris A 

PROVIDER: S-EPMC6006236 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature