Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics.

ABSTRACT:

Background

Single-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. It can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully differentiated cells. While a variety of statistical and computational methods have been proposed for inferring cell lineages, the problem of accurately characterizing multiple branching lineages remains difficult to solve.

Results

We introduce Slingshot, a novel method for inferring cell lineages and pseudotimes from single-cell gene expression data. In previously published datasets, Slingshot correctly identifies the biological signal for one to three branching trajectories. Additionally, our simulation study shows that Slingshot infe

SUBMITTER: Street K 

PROVIDER: S-EPMC6007078 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature