Proteomic Architecture of Human Coronary and Aortic Atherosclerosis.

ABSTRACT:

Backgound

The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets.

Methods

Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens). Convex analysis of mixtures, differential dependent network modeling, and bioinformatic analyses defined the composition, network rewiring, and likely regulatory features of the prot

SUBMITTER: Herrington DM 

PROVIDER: S-EPMC6011234 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature