Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study.

ABSTRACT:

Background

Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention would hasten and improve the appropriateness of empirical antibiotic administration, favor de-escalation, and decrease mortality.

Methods

We prospectively studied all consecutive patients with sepsis/septic shock admitted to 72 intensive care units (ICUs) throughout Spain in two 4-month periods (before and immediately after the 3-month intervention). We compared process-of-care variables (resuscitation bundle and time-to-initiation, appropriateness, and de-escalation of empirical antibiotic treatment) and outcome variables between the two cohorts. The primary

SUBMITTER: Ferrer R 

PROVIDER: S-EPMC6013897 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature