Catalytic radical reduction in aqueous solution via oxidation of biologically-relevant alcohols.

ABSTRACT: Metalloenzymes that normally perform catalytic antioxidant or radical-degrading functions, as well as small-molecule complexes that mimic them, can also exert pro-oxidant or radical-forming effects depending on the identity of the terminal reductant. Because nitroxyl radicals function as redox active cocatalysts in the aerobic oxidation of alcohols, we hypothesized that catalytic radical reduction could be achieved via the oxidation of biologically-relevant alcohols. Herein we report an organoruthenium complex (Ru1) that catalyzed reduction of 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonate) radical monoanion (ABTS˙^-) to ABTS^2- in phosphate buffered saline (pH 7.4) using MeOH, EtOH, i-PrOH, serine, threonine, glucose, arabinose, methyl lactate or dime

SUBMITTER: Htet Y 

PROVIDER: S-EPMC6013915 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature