Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning.

ABSTRACT: In current models, learning the relationship between environmental stimuli and the outcomes of actions involves both stimulus-driven and goal-directed systems, mediated in part by the DLS and DMS, respectively. However, though these models emphasize the importance of the DLS in governing actions after extensive experience has accumulated, there is growing evidence of DLS engagement from the onset of training. Here, we used in vivo photosilencing to reveal that DLS recruitment interferes with early touchscreen discrimination learning. We also show that the direct output pathway of the DLS is preferentially recruited and causally involved in early learning and find that silencing the normal contribution of the DLS produces plasticity-related alterations in a PL-DMS circuit. These data provid

SUBMITTER: Bergstrom HC 

PROVIDER: S-EPMC6015733 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature