Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life.

ABSTRACT:

Introduction

Silica nanoparticles (SiO₂-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period.

Materials and methods

Herein, we investigated the effects of SiO₂-NPs (doses of 10, 20, or 50 mg with a particle size of ~91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m³, respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults.

Results

SiO₂-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the

SUBMITTER: Fu J 

PROVIDER: S-EPMC6018854 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature