Dataset Information

Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors.

ABSTRACT:

Background

Penile carcinoma (PC) is a rare, highly mutilating disease, common in developing countries. The evolution of penile cancer includes at least two independent carcinogenic pathways, related or unrelated to HPV infection.

Objectives

To estimate the prevalence, identify HPV genotypes, and correlate with clinicopathological data on penile cancer.

Methods

A retrospective cohort study involving 183 patients with PC undergoing treatment in a referral hospital in Goiânia, Goiás, in Midwestern Brazil, from 2003 to 2015. Samples containing paraffin embedded tumor fragments were subjected to detection and genotyping by INNO-LiPA HPV. The clinicopathological variables were subjected to analysis with respect to HPV positivity and used prevalence ratio (PR), adjusted prevalence ratio (PRa) and 95% confidence interval (CI) as statistical measures.

Results

The prevalence of HPV DNA in PC was 30.6% (95% CI: 24.4 to 37.6), high-risk HPV 24.9% (95% CI: 18.9 to 31.3), and 62.5% were HPV 16. There was a statistical association between the endpoints HPV infection and HPV high risk, and the variable tumor grade II-III (p = 0.025) (p = 0.040), respectively. There was no statistical difference in disease specific survival at 10 years between the HPV positive and negative patients (p = 0.143), and high and low risk HPV (p = 0.325).

Conclusions

The prevalence of HPV infection was 30.6%, and 80.3% of the genotypes were identified as preventable by anti-HPV quadrivalent or nonavalent vaccine. HPV infections and high-risk HPV were not associated with penile carcinoma prognosis in this study.

SUBMITTER: de Araujo LA

PROVIDER: S-EPMC6021089 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors.

de Araújo Lyriane Apolinário LA De Paula Adriano Augusto Peclat AAP de Paula Hellen da Silva Cintra HDSC Ramos Jessica Enocêncio Porto JEP de Oliveira Brunna Rodrigues BR De Carvalho Keila Patrícia Almeida KPA Guimarães Rafael Alves RA de Alencar Rita de Cássia Gonçalves RCG Duarte Eliza Carla Barroso ECB Rabelo Santos Silvia Helena SH Saddi Vera Aparecida VA Carneiro Megmar Aparecida Dos Santos MADS

PloS one 20180627 6

<h4>Background</h4>Penile carcinoma (PC) is a rare, highly mutilating disease, common in developing countries. The evolution of penile cancer includes at least two independent carcinogenic pathways, related or unrelated to HPV infection.<h4>Objectives</h4>To estimate the prevalence, identify HPV genotypes, and correlate with clinicopathological data on penile cancer.<h4>Methods</h4>A retrospective cohort study involving 183 patients with PC undergoing treatment in a referral hospital in Goiânia, ...[more]

PMID: 29949632

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Project description:BackgroundHPV persistent infection is a strong carcinogenic factor that can induce cervical cancer. Investigation of HPV epidemiology and genotype distribution is of great meaning for the development of cervical cancer prevention and control strategies.MethodsBy using PCR-based hybridization gene chip assay, HPV genotype was detected from 14,185 women that came from HEC (Health Examination Center) or OGOC (Obstetrics and Gynecology Outpatient Clinics) between 2015 and 2017 in Sichuan area. The epidemiology and genotype distribution as well as the relationship between HPV infection and histology/cytology abnormalities were analyzed.ResultsThe positivity rate of HPV was 23.84%. The HPV-positive rate of OGOC group (37.62%) was significantly higher than that of HEC group (15.29%), p < 0.05. The prevalence of HPV reached peak at age 41-50 (5.86%) in HEC group, but at age 21-30 (14.74%) in OGOC group. Of all the HPV positive women, single genotype infection was the most common form in both HEC and OGOC group (62.06% in total screening population, 74.36% in HEC group and 54.01% in OGOC group). Three most prevalent HPV types were HPV-52 (5.02%), 58 (3.61%), and 16 (3.24%) in total screening population. Of all the HPV positive women, the top three types were HPV-52 (20.93%), CP8304 (15.32%), and 58 (14.42%) in HEC group, while were HPV-52 (21.14%), 16 (16.34%), and 58 (15.61%) in OGOC group. HPV 52/16/58 accounted for 41.84% of cytology and 56.52% of histological abnormalities.ConclusionsWomen in Sichuan area were facing the great threat of HPV infection, especially the women aged between 21 ~ 30 or 41-50 years old. The priority HPV types were HPV 52, 58, and 16 in OGOC group, while were HPV 52, CP8304, and 58 in HEC group. HPV 52/16/58 accounted for the majority of cytology and histological abnormalities. Our analysis was found to be valuable for providing a scientific basis for the prevention and control strategies of cervical cancer in Sichuan area.

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Dataset Information

Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors.

Background

Objectives

Methods

Results

Conclusions

Publications

Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors.

Similar Datasets

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