DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.

ABSTRACT:

Background

This study assessed the associations between nine differentially methylated regions (DMRs) of imprinted genes in DNA derived from umbilical cord blood leukocytes in males and females and (1) birth weight for gestational age z score, (2) weight-for-length (WFL) z score at 1 year, and (3) body mass index (BMI) z score at 3 years.

Methods

We conducted multiple linear regression in n = 567 infants at birth, n = 288 children at 1 year, and n = 294 children at 3 years from the Newborn Epigenetics Study (NEST). We stratified by sex and adjusted for race/ethnicity, maternal education, maternal pre-pregnancy BMI, prenatal smoking, maternal age, gestational age, and paternal race. We also conducted analysis restricting to infants no

SUBMITTER: Gonzalez-Nahm S 

PROVIDER: S-EPMC6025828 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature