Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.
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ABSTRACT:
SUBMITTER: Liebov BK
PROVIDER: S-EPMC6026834 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher.
Liebov Benjamin K BK Arroyo Alejandro D AD Rubtsova Natalia I NI Osharovich Sofya A SA Delikatny E James EJ Popov Anatoliy V AV
ACS omega 20180625 6
The near-infrared fluorescent activatable smart probe Pyro-phosphatidylethanolamine (PtdEtn)-QSY was synthesized and observed to selectively fluoresce in the presence of phosphatidylcholine-specific phospholipase C (PC-PLC). PC-PLC is an important biological target as it is known to be upregulated in a variety of cancers, including triple negative breast cancer. Pyro-PtdEtn-QSY features a QSY21 quenching moiety instead of the Black Hole Quencher-3 (BHQ-3) used previously because the latter conta ...[more]
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