Dataset Information

Obesity may be erythropoietin dose-saving in hemodialysis patients.

ABSTRACT:

Background

In dialysis patients, the obesity-survival paradox still requires an explanation. Anemia and high doses of erythropoiesis-stimulating agents (ESAs) are associated with worse outcomes in the hemodialysis (HD) population. In the present study, we explored the relation between obesity and anemia control in a sample of maintenance HD patients in Egypt.

Methods

This multicenter observational study included 733 patients on maintenance HD from 9 hemodialysis centers in Egypt. Clinical and laboratory data as well as average doses of ESAs and parenteral iron were recorded. The erythropoietin resistance index (ERI) was calculated.

Results

Obesity, defined as a body mass index (BMI) ≥ 30 kg/m², was present in 22.6% of the studied population. The target hemoglobin level (10.0-11.5 g/dL) was achieved in 27.3% of non-obese and 25.3% of obese patients, with no significant difference. The median serum ferritin and the values of transferrin saturation index did not differ significantly between these two groups. The weekly ESA dose was significantly lower in obese than in non-obese patients (P = 0.0001). A trend toward higher ESA doses and ERI values was observed in patients with lower BMIs (P < 0.0001). Multiple linear regression revealed that the BMI and urea reduction ratio were the strongest predictors of the ERI.

Conclusion

Our study adds more evidence to obesity-associated advantages in HD patients. BMI may determine ESA response, with better responses observed in patients with higher BMIs.

SUBMITTER: El-Kannishy GM

PROVIDER: S-EPMC6027808 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Obesity may be erythropoietin dose-saving in hemodialysis patients.

El-Kannishy Ghada M GM Megahed Abir F AF Tawfik Mona M MM El-Said Ghada G Zakaria Rabab T RT Mohamed Nahed A NA Taha Eman M EM Ammar Alzhraa A AA Abd Eltawab Abeer M AM Sayed-Ahmed Nagy A NA

Kidney research and clinical practice 20180630 2

<h4>Background</h4>In dialysis patients, the obesity-survival paradox still requires an explanation. Anemia and high doses of erythropoiesis-stimulating agents (ESAs) are associated with worse outcomes in the hemodialysis (HD) population. In the present study, we explored the relation between obesity and anemia control in a sample of maintenance HD patients in Egypt.<h4>Methods</h4>This multicenter observational study included 733 patients on maintenance HD from 9 hemodialysis centers in Egypt. ...[more]

PMID: 29971210

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Dataset Information

Obesity may be erythropoietin dose-saving in hemodialysis patients.

Background

Methods

Results

Conclusion

Publications

Obesity may be erythropoietin dose-saving in hemodialysis patients.

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