How reliable are ADC measurements? A phantom and clinical study of cervical lymph nodes.

ABSTRACT: OBJECTIVE:To assess the reliability of ADC measurements in vitro and in cervical lymph nodes of healthy volunteers. METHODS:We used a GE 1.5 T MRI scanner and a first ice-water phantom according to recommendations released by the Quantitative Imaging Biomarker Alliance (QIBA) for assessing ADC against reference values. We analysed the target size effect by using a second phantom made of six inserted spheres with diameters ranging from 10 to 37 mm. Thirteen healthy volunteers were also scanned to assess the inter- and intra-observer reproducibility of volumetric ADC measurements of cervical lymph nodes. RESULTS:On the ice-water phantom, the error in ADC measurements was less than 4.3 %. The spatial bias due to the non-linearity of gradient fields was found to be 24 % at 8 cm from the isocen

SUBMITTER: Moreau B 

PROVIDER: S-EPMC6028847 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature