Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women.

ABSTRACT:

Context

Controlled, blinded studies of sex-hormone replacement in postmenopausal women using natural estradiol (E₂) and native progesterone (P) are few.

Objective

To delineate the effect of E₂ alone or with P on lipids and inflammatory markers.

Design

A placebo-controlled, double-masked, prospectively randomized study of 40 healthy, postmenopausal volunteers assigned to four treatment groups: placebo, intramuscular E₂, and/or micronized oral P for 23 (±2) days.

Results

Treatment with E₂ alone compared with placebo lowered total cholesterol (TC; P = 0.006), non-high-density lipoprotein cholesterol (nonHDL-C; P = 0.004), low-density lipoprotein cholesterol (LDL-C; P = 0.012), and apolipoprotein B (A

SUBMITTER: Roelfsema F 

PROVIDER: S-EPMC6030831 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature