Ontology highlight
ABSTRACT:
SUBMITTER: Bellutti F
PROVIDER: S-EPMC6031305 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cancer discovery 20180613 7
Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages, the CDK6 kinase induces a complex transcriptional program to block p53 in hematopoietic cells. Cells lacking CDK6 kinase function are required to mutate <i>TP53</i> (encoding p53) to achieve a fully transformed immortalized s ...[more]