Transcriptomics

Dataset Information

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CDK6 antagonizes p53-induced responses during tumorigenesis


ABSTRACT: CDK6 induces a complex transcriptional program to block p53 in hematopoietic cells. CDK6 binds to the promoters of genes including p53-antagonists. Cells lacking CDK6 kinase function are required to mutate p53 to achieve a fully transformed immortalized state.

ORGANISM(S): Mus musculus

PROVIDER: GSE113752 | GEO | 2018/08/06

REPOSITORIES: GEO

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