HbA1c and hypoglycaemia in intensively treated type 2 diabetes: a retrospective cohort study in primary care.

ABSTRACT:

Objective

To establish whether low HbA1c is associated with clinical hypoglycaemia among people with type 2 diabetes prescribed insulins or sulphonylureas.

Design

Retrospective cohort study using routine electronic GP health records collected between January 2013 and December 2015.

Setting

Three east London Clinical Commissioning Groups.

Participants

Two cohorts of adults with type 2 diabetes prescribed either (i) insulins with or without other oral antidiabetic medication (n = 6788, 36.4%) or (ii) sulphonylureas with or without other oral antidiabetic medications excluding insulins (n = 11,840, 63.6%).

Main outcome measures

First clinically recorded hypoglycaemia and all-cause mortality. Hazard ratios (HR) adjusting for age, ethnicity, renal function an

SUBMITTER: Malawana M 

PROVIDER: S-EPMC6041855 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature