The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers.

ABSTRACT:

Background

Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instability (MSI), and to specific genomic driver lesions, including loss of PTEN, MYC amplification, and activating mutations in driver oncogenes such as KRAS and PIK3CA. Triple-negative breast cancers (TNBCs) typically have high levels of CNVs and diverse driver lesions in their genomes. Thus, there is significant interest in exploiting genomic data to develop predictive immunotherapy biomarkers for patients with TNBC.

Methods

Whole tissue samples from 55 resected TNBCs were screened by immunohistochemistry (IHC) for PD-1 and PD-L1 by using validated antibodies a

SUBMITTER: Barrett MT 

PROVIDER: S-EPMC6042255 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature