Ontology highlight
ABSTRACT:
SUBMITTER: Natividad JM
PROVIDER: S-EPMC6052103 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180718 1
Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly understood. Here, we showed that B. wadsworthia synergizes with high fat diet (HFD) to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis reveal pathways, particularly butanoate metabolism, which may unde ...[more]