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The stimulatory G protein G_sα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.

ABSTRACT: Central melanocortin 4 receptors (MC4Rs) stimulate energy expenditure and inhibit food intake. MC4Rs activate the G protein G_sα, but whether G_sα mediates all MC4R actions has not been established. Individuals with Albright hereditary osteodystrophy (AHO), who have heterozygous G_sα-inactivating mutations, only develop obesity when the G_sα mutation is present on the maternal allele because of tissue-specific genomic imprinting. Furthermore, evidence in mice implicates G_sα imprinting within the central nervous system (CNS) in this disorder. In this study, we examined the effects of G_sα in MC4R-expressing cells on metabolic regulation. Mice with homozygous G_sα deficiency in MC4R-expressing cells (MC4RGsKO) developed s

SUBMITTER: Podyma B

PROVIDER: S-EPMC6052205 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Dataset Information

The stimulatory G protein G_sα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The stimulatory G protein Gsα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The stimulatory G protein G_sα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.