Submicroscopic chromosomal imbalances contribute to early abortion.

ABSTRACT:

Background

Chromosomal abnormalities are one of the genetic mechanisms associated with abortion. However, the roles of submicroscopic chromosomal imbalances in early abortion are still unclear. This study aims to find out whether submicroscopic chromosomal imbalances contribute to early abortion.

Methods

A total of 78 chorionic villus specimens from early spontaneous abortion patients with no obvious abnormality are collected after miccroassay analysis (the case group). At the same time, 60 chorionic villus specimens from induced abortion patients with no obvious abnormality are selected as the control group. The submicroscopic structures of chromosomes from two groups are analyzed using an array-based comparative genomic hybridization (aCGH).

Results

In the case grou

SUBMITTER: Li H 

PROVIDER: S-EPMC6054741 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature