Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo.
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ABSTRACT:
SUBMITTER: Cheng D
PROVIDER: S-EPMC6062109 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport <i>in vivo</i>.
Cheng Dai D Wang Xiaomei X Xi Yu Y Cao Jiankang J Jiang Weibo W
Toxicology research 20171201 1
Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD). However, the mechanisms underlying Al-induced neurotoxicity are still largely elusive. Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3ζ protein have a high affinity for Al<sup>3+</sup>, and albumin has a much stronger affinity for Al than transferrin. The normal activity of CK-B, and ph ...[more]
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