Hormetic dose response to _L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression.

ABSTRACT: _L-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of _L-ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of _L-ascorbic acid. In this study, we demonstrate that _L-ascorbic acid treatment showed efficient anti-cancer activity in cell lines with high expression levels of SVCT-2 for a gradient concentration of _L-ascorbic acid from 10 μM -2 mM. However, in low SVCT-2 expressing cell lines, high-dose _L-ascorbic acid (>1 mM) showed anti-cancer effects but low-dose (<10 μM) treatment induced cell proliferation. Such conflicting results

SUBMITTER: Cho S 

PROVIDER: S-EPMC6063950 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature