Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts.

ABSTRACT:

Objective

Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas characterized by high recurrence rates and early metastases. These tumors arise more frequently within neurofibromatosis type 1 (NF1) and present with resistance during standard chemotherapy leading to increased mortality and morbidity in those patients. In vitro all-trans retinoic acid (ATRA) and MEK inhibitors (MEKi) were shown to inhibit tumor proliferation, especially when applied in combination. Therefore, we established a nude mouse model to investigate if treatment of xenografts derived from NF1 associated S462 and T265 MPNST cells respond to ATRA and the MEKi PD0325901.

Results

We demonstrated that human NF1 associated MPNST derived from S462 but not T265 cells form solid subcutaneous

SUBMITTER: Fischer-Huchzermeyer S 

PROVIDER: S-EPMC6064132 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature