Insula-Retrosplenial Cortex Overconnectivity Increases Internalizing via Reduced Insight in Autism.

ABSTRACT:

Background

Internalizing symptoms like anxiety and depression are common and impairing in autism spectrum disorder (ASD). Here, we test the hypothesis that aberrant functional connectivity among three brain networks (salience network [SN], default mode network [DMN], and frontoparietal network [FPN]) plays a role in the pathophysiology of internalizing in ASD.

Methods

We examined the association between resting-state functional connectivity and internalizing in 102 adolescents and young adults with ASD (n = 49) or typical development (n = 53). Seed-to-target functional connectivity was contrasted between adolescents and young adults with ASD and typically developing subjects using a recent parcellation of the human cerebral cortex, and connections that were aberrant in ASD w

SUBMITTER: Hogeveen J 

PROVIDER: S-EPMC6067993 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature