Expression profile of circulating microRNAs in the Correa pathway of progression to gastric cancer.

ABSTRACT:

Background

Helicobacter pylori infection causes long-term chronic active gastritis, a risk factor for the intestinal and diffuse forms of gastric cancer. Most gastric cancers develop in a stepwise progression from chronic active gastritis to precursor lesions of gastric cancer. The early detection of gastric cancer improves survival. Studies with recent evidence have proposed circulating-microRNAs as biomarkers of cancer.

Objective

The purpose of this study was to explore the circulating-microRNA profile from H. pylori infection to gastric adenocarcinoma.

Methods

One hundred and twenty-three patients were enrolled and assigned to the discovery or the validation sets. In the discovery phase, circulating-microRNAs were measured by dye-based quantitative po

SUBMITTER: Lario S 

PROVIDER: S-EPMC6068781 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature