Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface.

ABSTRACT: HLA-B*27:05 is associated with the development of autoimmune spondyloarthropathies, but the precise causal relationship between the MHC haplotype and disease pathogenesis is yet to be elucidated. Studies focusing on the structure and cellular trafficking of HLA-B*27:05 implicate several links between the onset of inflammation and the unusual conformations of the molecule inside and at the surface of antigen presenting cells. Several lines of evidence emphasize the emergence of those unnatural protein conformations under conditions where peptide loading onto B*27:05 is impaired. To understand how cellular factors distinguish between poorly loaded molecules from the optimally loaded ones, we have investigated the intracellular transport, folding, and cell surface expression of this particula

SUBMITTER: Hein Z 

PROVIDER: S-EPMC6071996 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature