Evolutionary stability of topologically associating domains is associated with conserved gene regulation.

ABSTRACT:

Background

The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation by restricting chromatin interactions of regulatory sequences, such as enhancers, with their target genes. Disruption of TADs can result in altered gene expression and is associated to genetic diseases and cancers. However, it is not clear to which extent TAD regions are conserved in evolution and whether disruption of TADs by evolutionary rearrangements can alter gene expression.

Results

Here, we hypothesize that TADs represent essential functional units of genomes, which are stable against rearrangements during evolution. We investigat

SUBMITTER: Krefting J 

PROVIDER: S-EPMC6091198 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature