Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC6092215 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20180719 2
Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we identified microtubule-associated serine/threonine kinase 1 (MAST1) as a main driver of cisplatin resistance in human cancers. Mechanistically, cisplatin but no other DNA-damaging agents inhibit the MAPK pathway by dissociating cRaf from MEK1, while MAST1 replaces cRaf to reactivate the MAPK pathway in a cRaf-independent manner. We show clinica ...[more]