Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future.

ABSTRACT: Recent improvements in high-throughput proteomic approaches are likely to constitute an essential advance in biomarker discovery, holding promise for improved personalized care and drug development. These methodologies have been applied to study multivariate protein patterns and provide valuable data of peripheral tissues. To highlight findings of the last decade for three of the most common psychiatric disorders, namely schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD), we queried PubMed. Here we delve into the findings from thirty studies, which used proteomics and multiplex immunoassay approaches for peripheral blood biomarker exploration. In an explorative approach, we ran enrichment analyses in peripheral blood according to these results and ascertained th

SUBMITTER: Comes AL 

PROVIDER: S-EPMC6095863 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature