Production of complex viral glycoproteins in plants as vaccine immunogens.

ABSTRACT: Plant molecular farming offers a cost-effective and scalable approach to the expression of recombinant proteins which has been proposed as an alternative to conventional production platforms for developing countries. In recent years, numerous proofs of concept have established that plants can produce biologically active recombinant proteins and immunologically relevant vaccine antigens that are comparable to those made in conventional expression systems. Driving many of these advances is the remarkable plasticity of the plant proteome which enables extensive engineering of the host cell, as well as the development of improved expression vectors facilitating higher levels of protein production. To date, the only plant-derived viral glycoprotein to be tested in humans is the influenza haemag

SUBMITTER: Margolin E 

PROVIDER: S-EPMC6097131 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature