KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc.

ABSTRACT:

Background

Cancer cells maintain energy metabolism mainly by glycolysis, even under sufficient oxygen conditions. It gives cancer cells better growth advantages under complicated internal environment. KPNA2 is a novel oncogene that has received much attention in recent years, but the exact mechanisms of KPNA2 in tumorigenesis and progression are largely unknown. Especially its potential roles in the metabolic transformation of tumors still remain to be explored.

Methods

The expressions of KPNA2 in glioblastoma and normal human brain samples were analyzed by immunohistochemical analysis. The activities of key enzymes in glycolysis, the production of lactate acid and glucose uptake were investigated by colorimetry. GLUT-1 expression was measured by flow cytometry. CCK8 was use

SUBMITTER: Li J 

PROVIDER: S-EPMC6097452 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature