Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure.

ABSTRACT:

Background

Primary cilia are small non-motile microtubule and cell membrane protrusions expressed on most vertebrate cells, including cortical and hippocampal neurons. These small organelles serve as sensory structures sampling the extracellular environment and reprogramming the transcriptional machinery in response to environmental change. Primary cilia are decorated with a variety of receptor proteins and are necessary for specific signaling cascades such as the Sonic hedgehog (Shh) pathway. Disrupting cilia structure or function results in a spectrum of diseases collectively referred to as ciliopathies. Common to human ciliopathies is cognitive impairment, a symptom also observed in Alzheimer's disease (AD). One hallmark of AD is accumulation of senile plaques composed of neurot

SUBMITTER: Vorobyeva AG 

PROVIDER: S-EPMC6098584 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature