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Reading cytosine modifications within chromatin.

ABSTRACT: Zinc-finger and homeodomain transcription factors have been shown in vitro to bind to recognition motifs containing a methylated CpG. However, accessing these motifs in vivo might be seriously impeded by the inclusion of DNA in nucleosomes and by the condensed structure adopted by chromatin formed on methylated DNA. Here, we discuss how oxidation of 5-methylcytosine into 5-hydroxymethylcytosine could provide the initial destabilizing clue for such transcription factors to get access to nucleosomal DNA and read epigenetic information.

SUBMITTER: Mahe EA 

PROVIDER: S-EPMC6104689 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Reading cytosine modifications within chromatin.

Mahé Elise A EA   Madigou Thierry T   Salbert Gilles G  

Transcription 20180206 4

Zinc-finger and homeodomain transcription factors have been shown in vitro to bind to recognition motifs containing a methylated CpG. However, accessing these motifs in vivo might be seriously impeded by the inclusion of DNA in nucleosomes and by the condensed structure adopted by chromatin formed on methylated DNA. Here, we discuss how oxidation of 5-methylcytosine into 5-hydroxymethylcytosine could provide the initial destabilizing clue for such transcription factors to get access to nucleosom  ...[more]

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