Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation.

ABSTRACT: House dust mites (HDMs) are one of the most significant environmental allergens in the establishment of the so-called "Atopic March." It is known that the immune response to HDM is Th2 dominant, but the innate mechanisms leading to HDM-induced type 2 responses are still not completely understood. A number of innate immune receptors have been implicated in the response to HDM including toll-like receptors, C-type lectin receptors, and protease activated receptors. NOD2 is a member of the NOD-like receptor family, which has been reported to be involved in the establishment of type 2 immunity and in blocking respiratory tolerance. NOD2 mediates its effects through its downstream effector kinase, receptor interacting protein (RIP2). It has not been shown if RIP2 is involved in the innate respo

SUBMITTER: Miller MH 

PROVIDER: S-EPMC6113092 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature